연구원 소개

• • 

  • 병원장 | 이 희 용

    서울대학교 치과대학 졸업
    서울대학교 대학원 치의학 박사
    서울대학교 치과대학 외래교수
    가천의과대학 외래교수
    대한 임플란트 학회 정회원
    미국임플란트학회(AO) 정회원
    대한치주과학회 정회원
    대한구강보건학회 정회원
    ITI 정회원 (INTERNATIONAL TEAM FOR IMPLANTOLOGY)
    ITI STUDY CLUB DIRECTOR
    PENNSYLVANIA 치과대학 치주과 초빙
    경북대학교, 서울보건대학교 외래교수
    한국보건사회연구원
    AIC 임플란트 임상지도교수
    연세대학교 치위생학과 겸임교수
    서울대학교 치의학 대학원 겸임교수

  논문

  • 간식별 치아우식유발가능정도에 관한 연구 / 이희용, 대한구강보건학회지 2002,002년 2월
  • 도시관급수 및 시판지하수의 불소이온농도에 관한 조사연구 / 문혁수; 백대일; 김종배; 이희용 대한구강보건학회지 2001, 25, 61-77
  • 치과병의원 내원환자 대상 구취조절진료에 따른 구취수준 감소효과 / 하정은; 이희용; 정진환; 백대일; 배광학 대한구강보건학회지 2010, 34, 491-497
  • 임플란트 종류 및 식립부위에 따른 안정성에 대한 RFA 분석 / 이희용, 박민주, 조현재, 유기준, 하정은, 백대일, 배광학 대한치과의사협회지 2012, 50(1), 31-37
  • Lee, J.B.; Yi, H.Y.; Bae, K.H. The association between periodontitis and dyslipidemia based on the Fourth Korea National Health and Nutrition Examination Survey. Journal of clinical periodontology 2013, 40, 437-442.Lee, J.B.; Yi, H.Y.; Bae, K.H.
  • Association between harmful alcohol use and periodontal status according to gender and smoking. BMC Oral Health 2014, 14, 1-6.Kim, H.-S.; Son, J.-H.; Yi, H.-Y.; Hong, H.-K.; Suh, H.-J.; Bae, K.-H.
  • 민관협력 노인구강건강증진사업 수혜자 평가 / 이희용; 유기준; 이수진; 정민지; 정수빈; 문애란; 목보람; 송연희 대한구강보건학회지 2014, 38, 41-49.

  저서

  • 구강보건인력의 배치및 활용방안. 한국보건사회연구원 1996
  • <번역> 구강감염과 전신건강 (분자생물학에서 치과진료 적용까지) 파라사이언스

• • 

  • 연구소장 | 이 해 암

    경북대학교 유전공학과 졸업
    경북대학교 의학과 석사
    경북대학교 치의학과 박사
    경북대학교 치과대학 조교
    대구보건대학교 강사
    경북대학교 의과대학 박사 후 연구원
    MD anderson cancer center 박사 후 연구원
    경북대학교 의과대학 학술연구교수
    경희대학교 의과대학 학술연구교수

  논문

  • Antiproliferation and Antiencystation Effect of Class II Histone Deacetylase Inhibitors on Acanthamoeba castellanii. Chu KB, Lee HA, Pflieger M, Fischer F, Asfaha Y, Alves Avelar LA, Skerhut A, Kassack MU, Hansen FK, Schöler A, Kurz T, Kim MJ, Moon EK, Quan FS. ACS Infect Dis. 2022 Jan 7
  • Detection of Acanthamoeba spp. using carboxylesterase antibody and its usage for diagnosing Acanthamoeba-keratitis. Kim MJ, Chu KB, Lee HA, Quan FS, Kong HH, Moon EK. PLoS One. 2022 Jan 5;17(1):e0262223.
  • Comparative analysis of differentially expressed genes in Acanthamoeba after ingestion of Legionella pneumophila and Escherichia coli. Moon EK, Kim MJ, Lee HA, Quan FS, Kong HH. Exp Parasitol. 2022 Jan;232:108188.
  • Glutathione Peroxidase 8 Suppression by Histone Deacetylase Inhibitors Enhances Endoplasmic Reticulum Stress and Cell Death by Oxidative Stress in Hepatocellular Carcinoma Cells. Lee HA, Chu KB, Moon EK, Quan FS. Antioxidants (Basel). 2021 Sep 22;10(10):1503..
  • Influenza Virus-like Particle (VLP) Vaccines Expressing the SARS-CoV-2 S Glycoprotein, S1, or S2 Domains. Chu KB, Kang HJ, Yoon KW, Lee HA, Moon EK, Han BK, Quan FS. Vaccines (Basel). 2021 Aug 18;9(8):920.
  • Histone Deacetylase Inhibitor-Induced CDKN2B and CDKN2D Contribute to G2/M Cell Cycle Arrest Incurred by Oxidative Stress in Hepatocellular Carcinoma Cells via Forkhead Box M1 Suppression. Lee HA, Chu KB, Moon EK, Quan FS. J Cancer. 2021 Jun 22;12(17):5086-5098. doi: 10.7150/jca.60027. eCollection 2021.
  • Chorismate mutase peptide antibody enables specific detection of Acanthamoeba. Lee HA, Chu KB, Kim MJ, Quan FS, Kong HH, Moon EK. PLoS One. 2021 Apr 23;16(4):e0250342. doi: 10.1371/journal.pone.0250342. eCollection 2021.
  • Identification of differentially expressed Legionella genes during its intracellular growth in Acanthamoeba. Quan FS, Kong HH, Lee HA, Chu KB, Moon EK. Heliyon. 2020 Oct 12;6(10):e05238. doi: 10.1016/j.heliyon.2020.e05238. eCollection 2020 Oct.
  • Production of a polyclonal antibody against inosine-uridine preferring nucleoside hydrolase of Acanthamoeba castellanii and its access to diagnosis of Acanthamoeba keratitis. Park SM, Lee HA, Chu KB, Quan FS, Kim SJ, Moon EK. PLoS One. 2020 Sep 30;15(9):e0239867.
  • Application of Histone Deacetylase Inhibitors MPK472 and KSK64 as a Potential Treatment Option for Acanthamoeba Keratitis. Lee HA, Park SM, Chu KB, Quan FS, Kurz T, Pflieger M, Moon EK. Antimicrob Agents Chemother. 2020 Nov 17;64(12):e01506-20.
  • Preliminary Trichinella spiralis Infection Ameliorates Subsequent RSV Infection-Induced Inflammatory Response. Chu KB, Lee HA, Kang HJ, Moon EK, Quan FS. Cells. 2020 May 25;9(5):1314.
  • Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive but not Dahl salt-resistant rats. Lee E, Kim N, Kang J, Yoon S, Lee HA, Jung H, Kim SH, Kim I. Dis Model Mech. 2020 May 27;13(5):dmm044107.
  • Combination of tert-butyl hydroperoxide with vorinostat induces cell death of Acanthamoeba through cell cycle arrest. Lee HA, Moon EK, Quan FS. Exp Parasitol. 2020 Mar;210:107833.
  • Sensitization to oxidative stress and G2/M cell cycle arrest by histone deacetylase inhibition in hepatocellular carcinoma cells. Lee HA, Chu KB, Moon EK, Kim SS, Quan FS. Free Radic Biol Med. 2020 Feb 1;147:129-138.
  • Histone Deacetylase Inhibitors Enhance the Amoebicidal Effect of Low Concentration of Polyhexamethylene Biguanide by Inducing Apoptosis. Quan FS, Lee HA, Kong HH, Moon EK. Cornea. 2020 Feb;39(2):245-249.
  • Resistance against Trichinella spiralis infection in pups delivered by T. spiralis-infected dam. Chu KB, Lee HA, Moon EK, Quan FS. Vet Parasitol. 2019 Sep;273:60-66.
  • Histone deacetylase inhibitor MGCD0103 protects the pancreas from streptozotocin-induced oxidative stress and β-cell death. Lee HA, Lee E, Do GY, Moon EK, Quan FS, Kim I. Biomed Pharmacother. 2019 Jan;109:921-929.
  • Repression of Transcriptional Activity of Forkhead Box O1 by Histone Deacetylase Inhibitors Ameliorates Hyperglycemia in Type 2 Diabetic Rats. Cho HM, Seok YM, Lee HA, Song M, Kim I. Int J Mol Sci. 2018 Nov 9;19(11):3539.
  • Upregulation of C/EBPβ and TSC2 by an HDAC inhibitor CG200745 protects heart from DOCA-induced hypertrophy. Lee E, Lee HA, Kim M, Do GY, Cho HM, Kim GJ, Jung H, Song JH, Cho JM, Kim I. Clin Exp Pharmacol Physiol. 2019 Mar;46(3):226-236.
  • Histone deacetylase inhibition attenuates hepatic steatosis in rats with experimental Cushing's syndrome. Kim M, Lee HA, Cho HM, Kang SH, Lee E, Kim IK. Korean J Physiol Pharmacol. 2018 Jan;22(1):23-33.
  • Histone deacetylase inhibition ameliorates hypertension and hyperglycemia in a model of Cushing's syndrome. Lee HA, Kang SH, Kim M, Lee E, Cho HM, Moon EK, Kim I. Am J Physiol Endocrinol Metab. 2018 Jan 1;314(1):E39-E52.
  • DNA Methylation of Gene Expression in Acanthamoeba castellanii Encystation. Moon EK, Hong Y, Lee HA, Quan FS, Kong HH. Korean J Parasitol. 2017 Apr;55(2):115-120.
  • Identification and Characterization of Protein Arginine Methyltransferase 1 in Acanthamoeba castellanii. Moon EK, Kong HH, Hong Y, Lee HA, Quan FS. Korean J Parasitol. 2017 Apr;55(2):109-114.
  • Forkhead box O3 plays a role in skeletal muscle atrophy through expression of E3 ubiquitin ligases MuRF-1 and atrogin-1 in Cushing's syndrome. Kang SH, Lee HA, Kim M, Lee E, Sohn UD, Kim I. Am J Physiol Endocrinol Metab. 2017 Jun 1;312(6):E495-E507.
  • Histone deacetylase inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in DOCA-induced hypertensive rats. Lee E, Song MJ, Lee HA, Kang SH, Kim M, Yang EK, Lee do Y, Ro S, Cho JM, Kim I. Korean J Physiol Pharmacol. 2016 Sep;20(5):477-85.
  • Histone deacetylase inhibition, but not a mineralocorticoid receptor antagonist spironolactone, attenuates atypical transcription by an activating mutant MR (MRS 810L ). Kang SH, Lee HA, Lee E, Kim M, Kim I. Clin Exp Pharmacol Physiol. 2016 Oct;43(10):995-1003.
  • Lysine deacetylase inhibition attenuates hypertension and is accompanied by acetylation of mineralocorticoid receptor instead of histone acetylation in spontaneously hypertensive rats. Seok YM, Lee HA, Park KM, Hwangbo MH, Kim IK. Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul;389(7):799-808.
  • Histone Deacetylase 3 and 4 Complex Stimulates the Transcriptional Activity of the Mineralocorticoid Receptor. Lee HA, Song MJ, Seok YM, Kang SH, Kim SY, Kim I. PLoS One. 2015 Aug 25;10(8):e0136801.
  • Lysine acetyltransferases cyclic adenosine monophosphate response element-binding binding protein and acetyltransferase p300 attenuate transcriptional activity of the mineralocorticoid receptor through its acetylation. Seo M, Song M, Seok YM, Kang SH, Lee HA, Sohn UD, Kim IK. Clin Exp Pharmacol Physiol. 2015 May;42(5):559-66.
  • Histone deacetylase inhibition attenuates cardiac hypertrophy and fibrosis through acetylation of mineralocorticoid receptor in spontaneously hypertensive rats. Kang SH, Seok YM, Song MJ, Lee HA, Kurz T, Kim I. Mol Pharmacol. 2015 May;87(5):782-91.
  • Protein kinase CK2 contributes to diminished small conductance Ca2+-activated K+ channel activity of hypothalamic pre-sympathetic neurons in hypertension. Pachuau J, Li DP, Chen SR, Lee HA, Pan HL. J Neurochem. 2014 Sep;130(5):657-67.
  • mGluR5 Upregulation increases excitability of hypothalamic presympathetic neurons through NMDA receptor trafficking in spontaneously hypertensive rats. Li DP, Zhu LH, Pachuau J, Lee HA, Pan HL. J Neurosci. 2014 Mar 19;34(12):4309-17.
  • Recruitment of specificity protein 1 by CpG hypomethylation upregulates Na⁺-K⁺-2Cl⁻ cotransporter 1 in hypertensive rats. Cho HM, Lee HA, Kim HY, Lee DY, Kim IK. J Hypertens. 2013 Jul;31(7):1406-13; discussion 1413.
  • Histone deacetylase inhibition attenuates transcriptional activity of mineralocorticoid receptor through its acetylation and prevents development of hypertension. Lee HA, Lee DY, Cho HM, Kim SY, Iwasaki Y, Kim IK. Circ Res. 2013 Mar 29;112(7):1004-12.
  • Upregulation of the Na(+)-K(+)-2Cl(-) cotransporter 1 via histone modification in the aortas of angiotensin II-induced hypertensive rats. Cho HM, Lee DY, Kim HY, Lee HA, Seok YM, Kim IK. Hypertens Res. 2012 Aug;35(8):819-24.
  • Tissue-specific upregulation of angiotensin-converting enzyme 1 in spontaneously hypertensive rats through histone code modifications. Lee HA, Cho HM, Lee DY, Kim KC, Han HS, Kim IK. Hypertension. 2012 Mar;59(3):621-6.
  • Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically regulated during postnatal development of hypertension. Cho HM, Lee HA, Kim HY, Han HS, Kim IK. Am J Hypertens. 2011 Dec;24(12):1286-93.
  • Enrichment of (pro)renin receptor promoter with activating histone codes in the kidneys of spontaneously hypertensive rats. Lee HA, Lee DY, Lee HJ, Han HS, Kim I. J Renin Angiotensin Aldosterone Syst. 2012 Mar;13(1):11-8.
  • Differential antiproliferation effect of 2'-benzoyloxycinnamaldehyde in K-ras-transformed cells via downregulation of thiol antioxidants. Ock J, Lee HA, Ismail IA, Lee HJ, Kwon BM, Suk K, Lee WH, Hong SH. Cancer Sci. 2011 Jan;102(1):212-8.
  • Possible involvement of DNA methylation in NKCC1 gene expression during postnatal development and in response to ischemia. Lee HA, Hong SH, Kim JW, Jang IS. J Neurochem. 2010 Jul;114(2):520-9.

• • 

  • 예방과 과장 | 송 연 희

    서울대학교 치과대학 졸업
    서울대학교 대학원 예방치학 석사·박사
    서울대학교 치의학대학원 외래교수
    대한 예방치과 구강보건학회 평생회원
    접착치의학회 정회원
    구취조절연구회 정회원
    서울시 장애인재활협회 이사 역임

  논문

  • 석사논문 1993년- 도시관급수불화사업의 우식예방효과에 관한 추구조사연구
  • 박사논문 1999년- 도시관급수불화사업의 치아우식예방효과에 관한 조사연구
  • 청주시 관급수불화사업의 효과에 관한 연구-대한구강보건학회지 Vol.16, No.2 1992
  • 구강환경관리용품의 선택에 관한 조사연구-대한구강보건학회지 Vol.16 No.2 1992
  • 불화소다와 sanguinaria extract 배합세치제의 치면새균막형성억제효과와 구강연쇄상구균수 감소효과에 관한 실용실험적 연구- 대한구강보건학회지 Vol.16 No.2 1992
  • 전기진동 잇솔질의 치면세균막제거효과와 치아마모력에 관한 연구-대한구강보건학회지 Vol.16 No.1 1992
  • 도시관급수불화사업의 치아우식예방효과에 관한 2년간 추구조사연구-대한구강보건학회지 Vol.17 No.2 1993
  • 도시관급수불화사업의 치아우식예방효과에 관한 3년간 추구조사연구-대한구강보건학회지 Vol.18 No.2 1994
  • 청주시 관급수불화사업 효과에 관한 추구조사연구(V)-대한구강보건학회지 Vol.21 No.4 1997